[2] The purpose of the existence of Paleo-Siberian itself lies in its practicability and remains a grouping of convenience for a variety of unclassifiable language isolates located in Northeast Eurasia.

Some proposals for the relationship of languages located within the Paleo-Siberian group have been made by some scholars, including Edward Vajda, who suggests them to be related to the Na-Dené and Eskimo–Aleut families of Alaska and northern Canada.

This would correlate with the widespread idea that North America's aboriginal peoples migrated from present-day Siberia and other regions of Asia when the two continents were joined during the last ice age.

Ket, or more precisely the now largely extinct Yeniseian family, has been linked to the Na-Dené languages of North America.

[5][6][7] Juha Janhunen suggests the possibility that similar consonant stop systems in Koreanic and Nivkh may be due to ancient contact.