The Palestro-class were four destroyers of the Italian Regia Marina that saw service from the mid-1920s to World War II.

Eight ships were ordered, but because of wartime shortages of materials only four were eventually completed.

These four ships were laid down in 1917 at the Orlando shipyard in Livorno, but were not finally completed until 1921–1923.

The design was subsequently enlarged into the Sella-class destroyers, a design that was developed into a series of medium-sized Italian destroyer classes.

This article about a specific military ship or boat of Italy is a stub.