Palisades was operated by the Nuclear Management Company and owned by CMS Energy prior to the sale to Entergy on April 11, 2007.

Its single Combustion Engineering pressurized water reactor weighs 425 tons and has steel walls 8+1⁄2 inches (220 mm) thick.

The MPSC did not approve Consumer Energy's full request of $172 million, so Entergy decided to keep the plant open three years longer than planned.

[13] In December 2022, Holtec announced that it will reapply for funds from the Civil Nuclear Credit in order to restart Palisades.

[20] Spent fuel is stored outdoors in 21 16-foot-tall (4.9 m) storage casks, each containing 30 tons and resting on a concrete pad.

[23] The 2010 U.S. population within 10 miles (16 km) of Palisades was 28,644, a decrease of 4.5 percent in a decade, according to an analysis of U.S. Census data for msnbc.com.

[24] The Nuclear Regulatory Commission's estimate of the risk each year of an earthquake intense enough to cause core damage to the reactor at Palisades was 1 in 156,250, according to an NRC study published in August 2010.

[18] If successful, Palisades would become the first U.S. nuclear reactor to restart after its fuel has been removed and its license revised to prohibit further operation.

[32][33] The plan for a restart by Holtec International (based in Jupiter, Florida) got a boost after Wolverine Power Cooperative, a local power company, agreed to buy as much as 2/3 of the plant’s output starting as soon as late 2025, though additional hurdles, including sign off from federal nuclear regulators, remain.

In December 2023, Holtec International announced that it intended to build the first two of its SMR-300 small modular reactors at Palisades by mid-2030.