Together with a group of associates and collaborators, he developed in the city of Rome a large structure of apostolic activity, which included assisting the poor, the sick, and the marginalized; founding orphanages, institutions of charity, and shelters; and ministering to soldiers, workers, students, and prisoners.

[3] Not long after the death of his wife, Marianne, in 1880, English poet Coventry Patmore contacted the Pallotines about establishing a church in Hastings.

The Fathers opened a number of missions and schools until 1916, when with the Kamerun campaign of World War I, they relocated south to Spanish Guinea.

The Society conducts parishes, schools, missions, clinics, retreat houses, all types of charitable works, and the scientific Institute for Catholic Church Statistics in Poland.

The Pallottines also founded and direct the Catholic Apostolate Center in Washington, D.C., which develops programs to help strengthen the Society's mission.

The Irish Pallottines have served in England, Argentina, United States, Rome (Church of San Silvestro in Capite) and East Africa (Kenya, Uganda and Tanzania), as well as being entrusted with the running of two parishes, Corduff and Shankill, in the Archdiocese of Dublin.

[9] Jorge Mario Cardinal Bergoglio, SJ, later Pope Francis, opened the cause in Argentina for beatification—the first step towards sainthood—for five members of the Pallottine community.