Egypt's interior minister, Magdy Abdel Ghaffar, Prosecutor-General, Nabil Sadek, and other government officials arrived at the scene shortly after the bombing.

[8] Tanta's residents, who were demonstrating nearby, physically assaulted Major General Hossam el-Din Khalifa, head of the Gharbia's Security Directorate.

[3] The state of emergency declaration required approval from the Parliament of Egypt, after which Sisi would have the authority to increase the powers of the police in arrests, surveillance, and seizures.

[19] An online statement via the Amaq News Agency said, "A security detachment of the Islamic State carried out the attacks against the two churches in the cities of Tanta and Alexandria".

[26] Egyptian President Abdel Fattah el-Sisi summoned the national security council,[27] and said that those wounded could receive medical care at military hospitals.

[28] The Egyptian Council of Churches, through its secretary-general, priest Rifaat Fathy, expressed its condolences to the victims' relatives and to Pope Tawadros II, and announced its support to Sisi's swift response to the events and to the counter-terrorism efforts of the country's security apparatus.

[29] The head of Al-Azhar, Egypt's leading center for the study of Sunni Islam, Sheikh Ahmed el-Tayeb, denounced the deadly attacks, calling them a "despicable terrorist bombing that targeted the lives of innocents.

[60] The Holy See received news of the attacks while Pope Francis was holding the Palm Sunday mass in front of thousands in St. Peter's Square.

The Pope, who was due to visit Egypt on 28 April, offered his condolences to his "brother" Tawadros II and to "all of the dear Egyptian nation" during his speech, while praying for the dead and the wounded.

"[66] The international Muslim Brotherhood condemned the attack as "painfully tragic" and that "the blood of the innocent will be a curse on the oppressors" whilst stating blame was due to the government which took power after the 2013 coup in Egypt.