Over the years, with the growth of Columbia and the arrival of Fort Jackson, the hospital expanded.

Later renamed Richland Memorial Hospital, it moved in 1972 to its present location near the intersection of Bull St. and Harden St. Extension.

It is affiliated with the University of South Carolina, training future doctors, nurses and pharmacists.

[1] In January 2006, the 124 inpatient bed Prisma Health Heart Hospital, located on the Richland campus, opened its doors.

The $80 million, 200,000-square-foot (19,000 m2) hospital is the state's only freestanding facility specializing only in the prevention, diagnosis, and treatment of cardiovascular diseases.