Palmitoleoylation

Palmitoleoylation is type of protein lipidation where the monounsaturated fatty acid palmitoleic acid is covalently attached to serine or threonine residues of proteins.

[1][2] Palmitoleoylation appears to play a significant role in trafficking and targeting and function of Wnt proteins.

[3][4][5] O-Palmitoleoylation of Wnt proteins is catalysed by PORCN.

The inverse reaction is done by NOTUM.

[6]

In palmitoleoylation, a palmitoleoyl group (derived from palmitoleic acid , pictured above) is added.