On 27 January 2015 he was appointed the Minister for Health and Social Solidarity in the First Cabinet of Alexis Tsipras.

[1] On 23 September 2015, he became the Minister of the Interior and Administrative Reconstruction in the Second Cabinet of Alexis Tsipras.

Blinded at age 10 from the explosion of a German hand-grenade, a remnant of World War II, Kouroumblis took part in a number of student campaigns, and eventually became the leader of a "social uprising" of the blind.

He is a founding member of the World Blind Union and worked more generally in the areas of children protection, care for the elderly and people with disabilities.

Following Syriza's victory in the January 2015 legislative election, he was appointed Minister for Health and Social Solidarity, becoming the first disabled person to take any public office at the national government level in Greece.