Soutsos is known to be one of the pioneers of romanticism in Greek poetry and prose, as well as a visionary behind the new Olympic Games who inspired Evangelis Zappas to sponsor their revival.

He was homeschooled by many important intellectuals of that time, and from 1818 till 1820, he and his brother studied in the School of Chios by educators such as Neophytos Vamvas and Constantinos Vardalachos.

He was enthusiastic about the coming of King Otto and supported the work of the regency in his newspaper Helios (Ἥλιος; Greek for Sun)[5] until the enactment of the heterogeneous law in 1843, under which citizens born in occupied territories no longer had the right of employment in the public sector.

Overall, Soutsos' poems are dominated by the lyric and elegiac tone, with the main subjects being religion, love and freedom, and all influenced by French Romanticism.

Leander, the first novel of the freed Greek State, is an epistolary novel with heavy influence from Ugo Foscolo's The Last Letters of Jacopo Ortis and Goethe's The Sorrows of Young Werther.

Memoirs of a Parrot (Ἀπομνημονεύματα ἑνὸς ψιττακοῦ) follows the narrative of a talking animal commenting on and criticizing the behavior of humans, and Τρισχιλιόπηχος is a science fiction story.

Their feud sparked a small war of pamphlets from other pedants competing to expose grammatical inconsistencies, errors and phrases literally translated from French in the works of their rivals, with proposals for implementing their own sets of rules.

In 1833 he published the poem Dialogue of the Dead, in which the ghost of Plato surveys his tattered land in dismay, wonders if he is really looking at Greece and addresses:[9] Where are all your theaters and marble statues?

Moreover, on 18 October 1859, when his Olympic dream became reality, he published an account of the Games' events paying tribute to its sponsor, Evangelis Zappas.