Spyropoulos started his career at Delta Ethniki side Aittitos Spata, from where Panionios snatched him in July 2010 and placed him in the club's under-20 team.
[7] In July 2016, Spyropoulos dropped to the second level and signed a contract with Lamia,[8] with whom he celebrated promotion at the end of the season.
[9] He then moved clubs again, signing with fellow Football League Doxa Drama in September 2017.
[10] On 10 September 2018, he signed a contract with newly promoted side Aittitos Spata on a free transfer.
[12] Panagiotis shares the same last name as another full back who starred at Panionios, Greek international Nikos Spyropoulos.