Spyropoulos began his career with PAS Giannina in 2001, where he celebrated a promotion to the Alpha Ethniki during his first season.

Eight months later, and while he was about to be transferred to Panathinaikos along with his teammates Alexandros Tziolis and Evangelos Mantzios, he tested positive for elevated testosterone and was initially suspended for two years.

Henk Ten Cate, the manager had praised his ability by asking a "Spyropoulos for the right side" too, during the pre-season.

Two days before the winter transfer window closed Spyropoulos signed for Serie A side A.C. Chievo Verona.

[11] On 17 November 2007, Spyropoulos made his Greece national team debut in the 5–0 Euro 2008 qualifier defeat of Malta coming on for Vasilis Torosidis in the 46th minute.