Panaqolus is a genus of small catfish in the family Loricariidae native to rivers in tropical South America.

[1] Its members were formerly thought to belong to a clade of small-sized species in the genus Panaque, until this genus was separated from Panaque in 2001.

At times it has been considered a subgenus of Panaque, and the validity of the genus has been disputed by various authors and sources.

[2] Pseudoqolus koko was formerly considered to be a member of this genus, although it was reclassified as a member of the currently monotypic genus Pseudoqolus by Nathan K. Lujan, Christian A. Cramer, Raphael Covain, Sonia Fisch-Muller, and Hernán López-Fernández following a 2017 molecular phylogenetic analysis.

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