Coimbre played thirteen seasons in the Puerto Rican Professional Baseball League (LBPPR), with the Leones de Ponce.

Following his retirement, Coimbre worked as a coach and manager of teams in both the professional and amateur leagues of Puerto Rico.

There he began playing baseball under the training and supervision of Miguel Caratini and Antonio Gordan, two hall of famers in the local league.

[3] He subsequently transferred to Ponce High School, where the Instruction Department tried to have him removed of the athleticism team based on allegations that he had received payment as a student-athlete.

In high school, Coimbre played at the positions of pitcher and second baseman, and he was recommended by a member of the Leones de Ponce to team officials.

Leones de Ponce, the local team of the Puerto Rican amateur league, was about to play a series against the San Juan Athletics.

Leones de Ponce needed additional players, and Coimbre was selected by team owner Pipo Maldonado.

[5] Coimbre's first performance outside Puerto Rico was in the Dominican Republic, where he played for Sandino in Santiago de los Caballeros in 1927.

After the Puerto Rican league season came to an end in 1932, Coimbre went to work as a security guard in a penal institution and only played with a semi-professional team.

The season concluded with Buchipluma, a second team owned by Santa Marta's proprietor, winning the league's championship.

While playing with Licey, the team developed a rivalry with El Escogido, which gave Coimbre an opportunity to establish relationships with several players, from both countries.

[7] The team won the league's championship, but Coimbre decided not to attend the award ceremony, choosing to stay in his hotel room instead.

The next season Coimbre won his first batting championship in the Puerto Rican Professional Baseball League, finishing at .342 after connecting for base hits in 22 consecutive games.

Coimbre received a tribute at Yankee Stadium, where hundreds of Puerto Ricans reunited and awarded him a scroll and a ring recognizing his performance.

He was subsequently invited to play in the Liga Mexicana de Beisbol (Mexican Baseball League) for the first time in his career, and joined the Puebla club.

Coimbre experienced a similar pattern in the 1944–1945 LBPPR season, where he was unable to record a hit in the first games, but finished with his second batting championship.

During his time of inactivity, he worked in the Administration of Parks and Recreation, supervising softball games organized by local businessmen.

Coimbre's last game was against the Cangrejeros de Santurce, where a wild pitch re-injured his knee, prompting his decision to retire as a player.

Coimbre also worked in the administration of the Indios de Mayagüez, when the team traveled to play in Havana, Cuba.

In his first day as an amateur coach, Coimbre summoned the players to a conference, where he noted that if all of them felt like "stars" and played for statistics their collective performance would suffer.

[25] Also the building housing the Secretaría de Recreación y Deportes on Avenida Las Américas in Ponce is named "Francisco "Pancho" Coímbre".