Panhandle–Plains Historical Museum is a history museum located on the campus of West Texas A&M University in Canyon, Texas, United States, a small city south of Amarillo.

The museum's contents are owned and controlled by the Panhandle-Plains Historical Society, while West Texas A&M University and the Texas A&M University Board of Regents maintain and provide the facilities.

[1] The Panhandle-Plains Historical Society was founded in 1921 by faculty and students of West Texas State Teachers College and area supporters to preserve the history of pioneer life and natural history in the West Texas region.

The museum received financial assistance from the Commission of Control for the 1936 Texas Centennial.

Some of the permanent exhibits include "People of the Plains: Experiments in Living", displays the difference and similarities of past and present Southern Plains settlers; "Pioneer Town", a recreation of a small settlement in the Texas Panhandle in the early 1900s; "The Don D. Harrington Petroleum Wing", a two floor exhibit showing the Texas Panhandle's oil boom years in the 1920s and 1930s; and "The T-Anchor Ranch House", an exhibit outside of the museum which recreates the original house that was constructed in the late 1870s.