Making theatrical relationships with movie exhibition chains including Regal Entertainment Group, AMC Theatres, Cinemex, and Cinemark, the studio raised the level of theatrically-released Latino films.

The studio's first film was 2011's From Prada to Nada, which Lionsgate and Grupo Televisa announced it had commissioned for a television series that did not materialize in 2012.

Pantelion Films said that Latinos were the fastest growing segment of the movie going audience in the 2010s and were loyal DVD consumers.

New Line Cinema struck a deal with the director of Mi Familia, Gregory Nava, to produce feature films for the Latino market.

As the first decade of the 2000s continued, some Spanish-language films received theatrical distribution from Latino-based exhibitors including Cinema Latino or on art circuits.

The studio's debut film received an ALMA Award given to Alexa Vega as Favorite Movie Actor in a Comedy or Musical.

The studio's follow up film to Prada, No Eres Tú, Soy Yo, reached 226 theaters though brought in less money with $1.3 million.

[10] The studio also picked up the U.S. rights for the foreign film Saving Private Perez which was placed on 161 U.S. screens and brought in $1.4 million at the box office.

[12] The studio's follow-up film, Girl in Progress opened on Mother's Day weekend and would gross over $2 million domestically.

Late in 2016, Hemisphere Media Group partnered with Lionsgate to create a subscription video on demand service incorporating Pantelion's titles.

[20] In 2021, Hemisphere Media Group acquired full ownership rights to the Pantaya streaming service from Lionsgate for $124 million, following the latter's decision to focus on the expansion of its Starz brand.

Subsequently, in May 2022, TelevisaUnivision reached a deal with Hemisphere Media Group to acquire Pantaya, targeting the platform in order to fortify their own ViX streaming service.