It is located between the edge of the Chilcotin Plateau at Tatla Lake on its northeast and the Klinaklini River on its west, with a southeastern boundary along Mosley Creek, a major tributary of the Homathko River.

The range is 5,550 km2 (2,140 sq mi) in area and extremely rugged, with many sharp, glaciated peaks.

Most of the range's peaks have names of gods or other deities, e.g. Thoth, Hermes, Polyphemus, etc.

West across the Klinaklini River is the Ha-Iltzuk Icefield, which is the largest of the coastal icecaps of the southern Coast Mountains, larger than the Waddington Range's complex of glaciers and peaks or the Homathko Icefield.

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