Panther Creek is a river in Schoharie County in the state of New York.

DEC rates the water quality of the stream as Class C, suitable for fishing and non-contact human recreation.

The agency also adds a "(TS)", indicating that the stream's waters are ideal for trout spawning.

[3] The bridge over the creek on West Fulton Road (County Route 4) is prone to debris jams and overflowing during flood events.

There is a low spot on West Fulton Road slightly east of the bridge, that during a 25-year and higher flood, would overtop the right bank of the creek and flow over the low spot in the road.