Panther Junction is an unincorporated community located in Brewster County, Texas, United States.

The community is located inside Big Bend National Park.

The ZIP Code serving the community is 79834, which is addressed to Big Bend National Park.

[2] Panther Junction is located approximately twenty miles east of Study Butte.

[5] The district covers most of Big Bend National Park and Southeastern Brewster County.