Pantherophis is a genus of nonvenomous colubrid snakes endemic to central and eastern regions of North America.

The genus, which contains 10 recognized species, first appeared in the fossil record in the Middle Miocene around 16.3 million years ago.

Originally classified in the genus Elaphe, phylogenetic studies have found this taxon to be closely related to Pituophis.

As with all snakes Pantherophis is an obligate faunivore with a diet that consists of small mammals, birds, reptiles and amphibians, and even insects.

The corn snake (P. guttatus) is a popular pet reptile, due to the availability of captive-bred animals, their low maintenance and calm disposition, and the variety of color morphs.

[4] Each of the ten or so species can be further distinguished based on subtle characteristics, such as color markings, scale nuances, and geographic range.

Subsequent molecular studies have found support of the sister grouping between Pituophis and the North American Elaphe species, which resulted in the resurrection of the genus Pantherophis.