In 1496, he was the lone dissenter in the Venetian Senate concerning the policy of giving Maximilian I of Germany leadership of the Holy League.
He was one of the foremost advocates of the reversal of Venetian policy that culminated in the Treaty of Blois with Louis XII of France in 1499, although he sought to avoid being dragged into war with Milan.
[1] When informed of the defeat, he allegedly turned to his wife and asked for his cloak, saying "I wish to go to the Pregadi [Senate], and say four words and then die.
In noting his death, Sanuto, who praises his administration of Padua, describes him as "very wise, but stubborn" (sapientissimo ma ostinato).
[1] An inventory of his house was made on 1 August, revealing a luxurious standard of living.