However, she died childless, and Guinigi married Ilaria del Carretto, a member of a noble Ligurian family, who gave him a son, Ladislao.

She too died early, in 1406, and Paolo Guinigi commissioned to sculptor Jacopo della Quercia a funerary monument, now housed in the Cathedral of Lucca.

As a lord, Paolo strengthened the fortifications of Lucca and, in 1401, began the reconstruction of the Augustan Fortress built by Castracani in 1322 and dismantled in 1370.

He also boosted the commerce of Carrara marble, the bank activities and the manufacturing of silk products, calling masters from all Europe.

In 1429, the Republic of Florence attacked Lucca due to its alliance with Filippo Maria Visconti of Milan.