Bonomini's early works were done in a rococo style that later developed into neoclassical.
He left as a decorator of civil and sacred, but reached the popularity for his portraits, and especially for his caricatures.
One of his most noted works was scenes of the cycle of living skeletons that were commissioned by the Parish of Santa Grata Inter Vites Borgo Canale to remember the celebration of the Triduum of the dead.
These paintings, after being exposed annually during the Triduum of the Dead in the parish of Borgo Canale, were exhibited at the Palazzo Pitti in Florence in 1922, with great success.
Noteworthy are also some decorations of public and private buildings in the Bergamo area, as well as the collection of his drawings kept at the Civic Art Collections of the Sforza Castle in Milan.