[1] The phrase may also refer to an episode of Star Trek, "The Paradise Syndrome", and in this instance, deals with being overworked and needing a break, rather than a feeling of dissatisfaction related to achieving one's dreams.
The titular character in the Simon and Garfunkel song "Richard Cory" (based on the Edward Arlington Robinson poem of the same title) epitomizes paradise syndrome.
The only way for him to be cured usually involves a topsy-turvy game of cat-and-mouse with a stuffed "commodity" (children's toy) which he finds and then deliberately loses.
In the 1997 novel Night Train by Martin Amis, paradise syndrome is proffered as a possible explanation for the suicide of Jennifer Rockwell, a young woman who seemingly had everything: beauty, intelligence, health, a devoted lover and a stimulating career.
The investigation of her suicide reveals clues to another explanation that the central character, detective Mike Hoolihan, suspects Jennifer herself may have left as an elaborate decoy.