However, the earliest presence of Paraguayans as an ethnic group can be traced back much later, to the second foundation (and the real permanent settlement) of the city of Buenos Aires by Juan de Garay who sailed down Parana River from Asuncion accompanied by local Mestizo and Guarani families.

Very different from other immigrant communities in Argentina (European and Middle-Eastern), Paraguayan entrance has been large (with insignificant return rate) and constant even to these days which makes up to 40 years of sustained immigration that does not seem to stop or decline in the future.

In addition, due to geographical proximity facilitating movement and cultural exchange, 40% of the Paraguayan-born community is settled in provinces of the Northeastern region of Argentina, namely Misiones, Corrientes, Formosa, Santa Fe, Córdoba and Chaco, which are near the Argentina–Paraguay border.

Some cultural elements shared by Argentina and Paraguay include the consumption of Yerba Mate (Ilex paraguayensis) in the form of mate, a traditional infused drink with hot water claimed by Argentina, Paraguay and Uruguay as the national drink, as well as Tereré, a traditional infused drink with cold water and Mate cocido, a traditional infused drink with hot water, both originally from Paraguay; Chamame, folk music genre with its origins in Guarani Jesuit Missions mixed with European styles, and the use of the Guaraní Language, which is the official language of Paraguay and second official language of the Argentine Corrientes Province since 24 September 2004.

Ituzaingó Curuzú Cuatiá Caá Catí Cerro Corá Mburucuyá ("Passion flower" the National flower of Paraguay) Mocoretá Tabay ("small town") Tapebicua Tatacuá ("the hole of the fire") Taragui Yahapé Yataytí Calle Yapeyú Itatí Itá Ibaté ("tall stone") Guaviraví Vaca Cuá Ita Corá Aguay Oberá ("shiny") Caa Yarí Capiobí Caraguatay Garuhapé Garuhapé-Mi Garupá Guaraní Itacaruaré Mbopicuá ("hole of the bat") Panambí ("butterfly") Pindapoy Piray Kilómetro 18 Puerto Iguazú (Iguazú meaning "large water") Puerto Piray (Piray meaning "small fish") Tarumá Tacuaruzú Cuña-Pirú Samuhú ("Chorisia" a kind of subtropical tree) Colonia Tacuarí El Paranacito Aguaray Yariguarenda Yacuy El Aguay Acambuco Itangua Tobantirenda Capiazuti Tacuarendí ("sugarcane fields") El Arazá Caraguatay Aguará Grande Ñanducita ("small spider") Tacural ("anthills") Vera ("shiny") Carcarañá ("mean caracara") Añatuya Caburé Urutaú Tukumã Tapia ("wall") El Timbo Pirané ("smelly fish") Ibarreta Yatai Tatané Gualeguay Paraná Mandisoví Villaguay Ubajay Gualeguaychú Chajarí Ñancay Ibicuy Pehuajó, Reta "retã" ("country or nation"), Mar de Ajó, Mar del Tuyú, San Bernardo del Tuyú, Ituzaingó ("waterfall") Paraná Paraguay ("colorful water") Uruguay ("water of the birds") Carapari Gualeguay Gualeguaychú Guayquiraró Rivers of the Paraná Delta Ibicuy