It is also a key anatomic landmark for localizing disease processes in the surrounding spaces of the neck; the direction of its displacement indirectly reflects the site of origin for masses or infection in adjacent areas, and consequently their appropriate differential diagnosis.

The danger space serves as an important pathway for complicated infections of the posterior pharynx to enter the chest and spinal column.

[1] Although initial evaluation is typically by physical exam and endoscopy, follow up with CT and MRI usually is needed if surgical intervention is planned.

The parapharyngeal space is divided into 2 parts by the fascial condensation called the aponeurosis of Zuckerkandl and Testut (stylopharyngeal fascia - see diagram),[3] joining the styloid process to the tensor veli palatini.

[6] First bite syndrome is a rare complication of a surgery involving the parapharyngeal space, especially removal of the deep lobe of the parotid gland.