[5] Other significant towns in Pardubice Region are Hlinsko, Přelouč, Polička, Choceň, Holice, Letohrad and Žamberk.

The southern and southeastern parts of the region are home to the hilly areas of Upper Svratka Highlands and Iron Mountains.

The rivers in the drainage basin of the Danube are the Morava, Moravská Sázava, Svitava and Třebůvka.

Pardubice Region has a continental climate characterized by relatively hot summers and cold winters.

The areas in the Polabí lowlands in the western part of the region are relatively warmer with annual mean temperatures reaching 8 °C.

On the other hand, the coldest areas are situated in the hilly northeastern part of the region, where the annual mean temperatures are around 4 °C.

Precipitation is relatively lower in the central part of the region where the total annual values are around 700 – 800 mm.

General engineering, textiles, clothing, and leather processing are the strongest industrial branches.

There are 542 km of railways in the region, connecting it to Prague, Brno, Liberec, Olomouc, Ostrava, and to Poland.

The railway corridor of Berlin – Prague – Brno – Vienna crosses the region and in Pardubice it is connected to routes of national significance to Liberec and Havlíčkův Brod.

The most significant historical monuments in the region are connected with the noble Pernštejn family from Moravia, who had two huge castles built, at Litice nad Orlicí, and on Kunětická hora near Pardubice.