A new building houses Glenside Health Services at the southern end of the site, along with new wards and facilities.

[2][3] Erindale Secure Ward for Males, a lower security unit than the Z Ward, was built in 1877 and The Elms in 1880 to house female patients, although later used for elderly men, then as a Domestic Training Unit and for Music Therapy.

[2] From the 1970s onwards, with falling numbers and changing methods of treatment, the original site was progressively sold off, largely for housing, and some of the historic buildings refurbished for use by organisations such as SA Health, PIRSA, and ArtsSA.

[citation needed] Glenside Health Services was built at the southern end of the site in 2013, along with new facilities.

The centre opened with 129 beds, but the emphasis had shifted to more care provided at home and in the community, with only acute cases admitted to the facility for short periods.

In May 2019, an independent review conducted by two interstate experts and a representative of the Chief Psychiatrist's office found “attitudes and practices that are not in line with contemporary thinking” were prevalent in the ten-year-old 40-bed Inpatient Rehabilitation Service (IRS), as well as a building design unsuitable for longer-term residents.

[14] Funding was provided by the Government of South Australia for the refurbishment of the Erindale building in January 2025.