Though it may occur in drier environments, some specimens have been collected from humid microhabitats such as cavities below boulders and shaded areas near waterfalls.

Marked median depressions are present on the well-developed canthal ridges, and the ear opening is a vertical slit.

[4] Because all individuals in one study have been observed at night or near dusk, it is believed that Paroedura rennerae is a nocturnal species.

This lizard has been seen climbing large boulders, tree trunks and wooden walls of huts, reaching heights of around 1 to 2 m above the ground.

Similar to other species in the P. bastardi complex, P. rennerae is reported to be quick to bite when handled, likely as a defence mechanism.

[4] This gecko is known to coexist with the related Paroedura manongavato, which has a much more restricted range, in both localities the latter species is known to occur.