Serranía de la Macarena is an isolated mountain range located in the Meta Department, Colombia.

The first national reserve in Colombia was established in the central part of the mountain range in accordance with a Congressional Law promulgated in 1948.

[1] The status of National Natural Park was designated in 1971 and the protected area encompasses 6,200 km2 (2,400 sq mi).

The national park encompasses the ecologically unique meeting point for the flora and fauna of the Amazon, Orinoco and Andes regions.

The La Macarena National and Ecological Reserve Park is internationally known for the Caño Cristales, known by people who has visited it as one of the most beautiful rivers in the world.