He started off his acting career by featuring in Gumrah: End of Innocence as Siddharth and Best Friends Forever?

He rose to fame after portraying Manik Malhotra in Kaisi Yeh Yaariaan and Anurag Basu in Kasautii Zindagii Kay.

Samthaan rose to fame by playing Manik Malhotra from 2014 to 2015 in MTV India's Kaisi Yeh Yaariaan opposite Niti Taylor for seasons 1 and 2.

[7] In 2019, he played Faizal Alghazi in ALT Balaji's Kehne Ko Humsafar Hain 2 opposite Pooja Banerjee.

[9] In 2022, he returned to play Manik Malhotra in Voot's Kaisi Yeh Yaariaan 4 and 5[10] Samthaan made his Bollywood debut with the film Ghudchadi.