Primarily based in the city of Regina, the health region operated out of 8 hospitals, 10 community health centres, and numerous long-term care facilities and clinics.

[3] The city of Regina has two major hospitals that serve the local community as well as being referral centers within the region and province:

[4] The hospital is operated by the Regina Qu'Appelle Health Region.

It was opened in 1901 as the Victoria Hospital and had 25 beds initially.

[6] The Regina General Hospital is equipped to handle major life-saving emergencies and serves as southern Saskatchewan's major trauma centre.