He played college football for the Iowa Hawkeyes and was selected by the Indianapolis Colts in the second round of the 2010 NFL draft.

Angerer attended Bettendorf High School in Bettendorf, Iowa, where he recorded career totals of 344 tackles, including 63 tackles for loss, 17 quarterback sacks, five forced fumbles, four recovered fumbles and one interception while playing middle linebacker.

A team captain as a senior, he holds school records for tackles in a game (25), season (197) and career (344).

Working through mononucleosis, as well as hamstring, groin and shoulder injuries, Angerer finally made the starting lineup in 2008.

In 2011, Angerer was the starting middle linebacker for all 16 regular season games and he led the Colts in tackles with 148.

Angerer proposed to his high school sweetheart, Mary Beth Porter, after the Orange Bowl victory.