He is a graduate of Glenbrook North High School in Northbrook[1] and was twice named to the All-Mid-American Conference Second Team while attending Western Michigan University.

[6] In his first four seasons in the Giants farm system (through the end of 2006), Misch compiled a 30-28 won-lost record and a 3.52 ERA in 96 games (95 starts).

[7] He made his major league debut September 21, 2006, pitching a scoreless inning of relief and striking out the first batter he faced—Milwaukee Brewers' rookie left fielder Drew Anderson.

[8][9] Misch began the 2007 season pitching out of the bullpen of the former Giants' Triple-A, Pacific Coast League affiliate Fresno Grizzlies.

[25] Misch joined the Detroit Tigers on a minor league contract in January 2013,[26] underwent Tommy John surgery in August 2013,[27] and left the organization at the end of the year.

[28] He spent most of 2014 recovering from the operation and the 2014–15 Puerto Rico Baseball League season pitching for the Cangrejeros de Santurce.

[31] He played most of the season with the Triple A New Orleans Zephyrs and set a Pacific Coast League record on May 4, 2015, by hitting four straight batters with pitches in the first inning.

[27] The Monkeys trailed the Chinatrust Brothers 3–1 in the series, but forced a seventh and final game, which Misch won with a no-hitter.