The 1954–55 Cangrejeros, nicknamed Panic Squad, was the team's most notable roster, with a lineup that included hall of famers Roberto Clemente and Willie Mays.

[2] Zorilla led a board composed of Ramírez de Arellano, Rafael Muñiz, Mike Pasarell, Héctor Nevares, Toño Palerm among others, which oversaw fund raising and operation.

[3] The first uniforms of the Cangrejeros were bought blank, and the numbers and names of the players were sewed on for free by the mother of former general manager and sportswriter Carlos Pieve, who was a baseball fanatic.

[2] The team's lineup included Agustín Daviu, the first Puerto Rican to play organized baseball in the United States, and Luis Raúl Cabrera, both from Ponce.

The league's rules allowed the inclusion of three foreign reinforcements, Zorilla contracted Negro leaguers Billy Byrd, Josh Gibson and Dick Seay to fill these spaces.

The rivalry between the Cangrejeros and Senadores became known as the "City Championship", a term coined by Zorilla as a publicity stunt, with San Juan winning the first banner of this matchup.

With the loss of Gibson, the team had signed Efraín Merced, Georgie Calderón, Raymond Brown and obtained Pedro Jaime Reyes in a trade for Concepción.

[5] The team finished this half with a record of 11 wins and 3 losses, gaining victories over the Grises de Humacao, Caguas, Mayaguez and Guayama.

In 1941–42, the Cangrejeros lost several close games, being unable to match Ponce, the team that won both halves led by Francisco Coimbre.

In 1942–43, Caguas lost its franchise and Santurce signed some of its players, including Luis Olmo, Sammy Céspedes and Manolo García.

[11] Gibson did not a hit a single home run throughout the season, experiencing an emotional breakdown that convinced Zorilla to send him back to Pittsburg.

In their first international competition, the Cangrejeros were reinforced with Olmo who had returned to Caguas, Roberto Vargas and José Santiago among others, winning the first Caribbean title for Puerto Rico.

After the first month of the season, the team was in the fourth place of the league's standing with a negative record, before winning straight games against the Senadores and Criollos.

[23] On October 31, 1954, Gómez pitched the league's first shutout, he finished with a record of 13-4 and won the "City Championship" and Caribbean Series title for Santurce.

[25] Five players were included in the event's All-Star lineup, Don Zimmer carried the MVP and the Cangrejeros received a special trophy for winning three Caribbean championships.

The team was forced to adjust its schedule to comply with the growing popularity of horse races, product of El Comandante hippodrome opening that year.

[37] The Cangrejeros finished last during the first half of the 1960–61 season and were the runner-up of the second, but this result eliminated them under a short-lived league format where only the winners of one the halves advanced to the finals.

[42] However, Pizarro was signed as the Indios' reinforcement for the Interamerican Series, pitching the only no-hitter in the event's history, which included ten strikeouts.

On January 9, 1965, the team was involved in an uncommon historic event, when Mayagüez's first baseman, Fred Hopke, did not receive the ball once, going throughout the game without recording an assist or out at first base.

Olmo returned to the manager office in 1965–66, but the team struggled during the initial half, losing ten straight games to open the season, being unable to recover, finishing last in the standing.

[49] Tony Pérez was selected the league's MVP, playing third base in a line up that included Cepeda, Gilberto Torres and Dave May.

The team's performance was inconsistent, while its import players did not record good numbers, which led to a fifth-place finish, being eliminated during the regular season.

[63] The following season, an executive vice president position was created just to allow participation to Zorilla, who also received a recognition for assembling the 1955 lineup and a new logo was debuted.

[72] In 1986–87, the team developed a three-year professional agreement with the Dodgers, which provided them with several prospects and staff members, including manager Kevin Kennedy.

The 1989–90 season was shortened by ten games due to Hurricane Hugo, which affected Puerto Rico's metropolitan area severely.

[76] The 1990–91 team included Beníquez, DeJesús, Sánchez, Mark Lemke, Junior Ortíz, Jaime Navarro, Candy Sierra and Luis Aquino among others.

[79] The team's bullpen also recorded the league's lowest ERA, with 1.63, led by Oliveras, Greg Harris, José Lebrón and Scott Bailes.

[81] Santurce went on to win their first Caribbean Series in four decades, relying on their pitching staff and Thon's offense, while Villanueva was named the event's MVP.

This performance led to the firing of three reinforcement players, Troy O'Leary, Carl Everett and Gerald Williams, the entire outfield was changed, while only Sierra was producing.

Participating in the now-renamed Puerto Rico Baseball League, the Santurce made the playoffs in their first season back after a four-year absence, but were eliminated in the first round.