After graduating, he joined the Cleveland Indians' farm system in 1941, and made his major league debut two-and-a-half years later.

[1] He attended Little Rock Catholic High School, where he played baseball and American football, serving as the team's starting fullback.

Almost immediately after his debut, he earned the nickname of "people's choice" in media due to both his hitting ability and his "willingness to challenge the brick walls of the stadium".

[9] Seerey moved back to left field to begin the season; in his first game there on the year, he hit a three-run home run to give the Indians a 7–4 victory over the Detroit Tigers.

[10] A month into the season, Seerey was among the league leaders in runs batted in, which was attributed to better plate discipline, though his fielding in the outfield was still considered a liability.

[17] He spent the second half of the season in and out of the starting lineup due to his inconsistent hitting; manager Boudreau felt that occasional rest days would increase his consistency.

[23] In spring training games, Seerey had nine home runs, and expectations were high for him; Boudreau gave him the starting job in left field for the opener against the White Sox.

At the end of June, Seerey was removed from the starting lineup and replaced by both Dale Mitchell and Hank Edwards; he spent the rest of the season playing part-time.

[6] After the 1947 season ended, Indians owner Bill Veeck put Seerey on a strict diet and exercise regimen for the offseason, stating that he had to lose 35 pounds if he wanted to remain on the team.

[26] By the start of spring training, he had reached his goal of 195 pounds, and felt like he had an easier time swinging the baseball bat as a result.

On June 2, Seerey was traded with Al Gettel to the White Sox for Bob Kennedy due to his inconsistency as well as an overstocked group of outfielders on the roster.

Seerey homered in three successive innings (fourth through sixth), hitting his first two off starting pitcher Carl Scheib and the third off reliever Bob Savage.

He had a problem with Seerey, who arrived overweight to spring training, and did not consider him worthy of practicing with the other players until he got the weight back down.

[32] He played for four minor league teams in 1949: Los Angeles, the Newark Bears, the Kansas City Blues, and the San Antonio Missions.