[6] In 2006, Stryker gave $500,000 to the Coalition for Progress, a political action committee that donated heavily to support Democratic party candidates in Michigan elections.
[6] Stryker donated $1.5 million to Priorities USA Action, a Super PAC supporting Democratic presidential candidate Hillary Clinton in 2016.
[12][13] Stryker, Jared Polis, Tim Gill, and Rutt Bridges are known in Colorado political circles as "The Four Horsemen" (aka "Gang of Four" or "The Four Millionaires") who have donated to liberal causes, fought against gerrymandering, and promoted progressive initiatives.
[6] According to New York Times reporter Matt Bai, Stryker attended the April 2005 meeting of the Democracy Alliance near Scottsdale, Arizona.
Stryker along with George Soros and other Democracy Alliance members Gail Furman; Paul Rudd (co-founder of Adaptive Analytics); John R. Hunting; Nicholas Hanauer; ex-Clinton administration official Rob Stein; Drummond Pike; real estate developer Robert Bowditch; Pioneer Hybrid International-heir and congressional candidate Scott Wallace; Susie Tompkins Buell; real estate developer Albert Dwoskin; and Taco Bell-heir Rob McKay, funded the Secretary of State Project, an American non-profit organisation, 527 political action committee focused on electing reform-minded progressive Secretaries of State in battleground states, who typically oversee the election process.