Patient Zero is a 2018 science fiction horror film directed by Stefan Ruzowitzky and written by Mike Le.

The film stars Matt Smith, Natalie Dormer, John Bradley, Stanley Tucci, Agyness Deyn, and Clive Standen.

After a bidding war between several studios over a script penned by Le, Screen Gems eventually won the rights.

Now with a large group of civilians, CDC scientists, and U.S. military in an underground nuclear base, Morgan and virologist Dr. Gina Rose bring in the infected and interrogate them, hoping to find the Patient Zero and devise a cure.

After a one-on-one fight with Knox, he is subdued and asks to speak with Morgan specifically, who is surprised that the patient is unaffected by the music that has driven the other infected into a rage.

Through a window in the door, Janet wipes a tear from her face, indicating that she was now able to cry and that the treatment was working and restoring her humanity, and mouths "I love you".

The script, initially titled Patient Z, was featured on the 2013 Black List, an annual survey showcasing the "most liked" motion picture screenplays unproduced.

[1] Set in a post-apocalyptic world full of zombies, the story follows a man who speaks their language questions the undead in order to find a cure for his infected wife.

[10] Some filming took place in Welwyn Garden City, Hertfordshire on 15 March 2015, where a SWAT van and car were seen on set.

[16] The film was promoted at San Diego Comic-Con 2016, which was attended by Smith, Dormer, Standen, Bradley, Ruzowitsky, and Le.

[17] Standen explained that the film's tension centers on the infected thinking they are "the new evolution of mankind" who want to wipe out the human race.

[19] Geoff Berkshire, writing for the Los Angeles Times, described the film as "a post-apocalyptic pandemic movie that’s more grade-Z than World War Z", and concluded: "A near future where a divided humankind is so full of anger at people different from themselves that they literally turn into monsters?

"[20] Jeffrey M. Anderson of Common Sense Media gave the film a score of 1 star out of 5, saying that it "eventually wanders cluelessly off track, but, as it consists mainly of yelling, sudden loud noises, and camera-shaking, it gets aggravating long before that happens.