Menas of Constantinople (also Minas; Ancient Greek: Μηνᾶς; died 25 August 552), considered a saint in the Chalcedonian-affirming Church and by extension both the Eastern Orthodox Church and Catholic Church of modern times, was born in Alexandria, and enters the records in high ecclesiastical office as presbyter and director of the Hospital of Sampson in Constantinople, where tradition has him linked to saint Sampson the Hospitable directly, and in the healing of Byzantine emperor Justinian I from the bubonic plague in 542.

At some date, very soon after his election, he received the order (keleusis) from the Emperor, whose text is not preserved, but which instructed him to call a synodos endemousa to examine the case of Anthimus, which would be heard at a series of five sessions, beginning on 2 May and ending 4 June 536.

[3] This Synod condemned Anthimus, as noted in Novellae Constitutiones XLII from Justinian, addressed directly to Menas.

[4] Within this same effort from Justinian to seal the growing rift between the Patriarch in Constantinople and that of Jerusalem, Menas later took a position against Origen, a crisis merging into the Three-Chapter Controversy, an attempt to condemn the writings of certain non-Chalcedonian figures.

Almost immediately after the events of 536, which may be viewed as a Chalcedonian victory over monophysites, the ordination of an independent network of alleged monophysite / self-professed miaphysite bishops claiming apostolic authority would begin, leading eventually to the formation of a separate non-Chalcedonian church, the still-existing Syrian Orthodox Church that would be in communion with other excommunicated sees of the same theological persuasion.