Nicephorus II of Constantinople (Greek: Νικηφόρος; died c. February 1261) was a Byzantine cleric and Ecumenical Patriarch of Constantinople in exile at the Empire of Nicaea.
Originally serving as Metropolis of Ephesus, he was elected to the patriarchate after the resignation of Arsenius of Constantinople in March 1260.
He died after a few months, in February 1261, and was buried at Nymphaion.
A period of vacancy followed his death, but after the reconquest of Constantinople in July, Arsenius was recalled from his retirement and restored to the patriarchal throne.
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