Her work included commercial cases in the areas of contracts, intellectual property, securities, and employment law.

She also served on the Attorney General's Transnational Organized Crime Task Force MS-13 Subcommittee.

[4] In 2017, Giles had been recommended among a list of individuals to fill the seat left vacant when Gerald Bruce Lee retired, but the Trump Administration nominated Rossie D. Alston Jr., who was confirmed.

[5] In April 2021, Senators Mark Warner and Tim Kaine recommended Giles to be a United States District Judge for the Eastern District of Virginia to the seat vacated by Judge Liam O'Grady.

President Biden nominated Giles to the seat vacated by Judge Liam O'Grady, who assumed senior status on May 1, 2020.