[5] She walked runways in ready-to-wear fashion shows for designers such as Chanel, Chloé, John Galliano, Claude Montana, Dolce & Gabbana and many others.

She also appeared on the Rod Stewart video "Leave Virginia Alone" and others, such as Ricardo Montaner "Para Llorar" and George Michael "Spinning the Wheel."

[8] Velásquez was appointed UNESCO Artist for Peace (Goodwill Ambassador) in June 2003, in the context of the International Decade for the World’s Indigenous People.

[9] in 2006, Velasquez was critically acclaimed for her debut stage performance in the lead role of School of the Americas at the Public Theater in New York City.

She also voiced the character Marisol Díez Delgado in SSX Tricky and Unuratu on the Shadow of the Tomb Raider video game.

The Awards Ceremony recognizes the valuable contribution of men, women, and institutions dedicated to the creation of a more equal society[11][12] Velásquez competed on behalf of the charity Wayúu Tayá Foundation on the twelfth season of The Apprentice.

[13] On August 30, 2018, the Organization of American States (OAS) appointed Velásquez as Goodwill Ambassador for the Rights of Indigenous Peoples of the Americas during a ceremony at its headquarters in Washington, DC.

In 2020, Velásquez played Nurse Velasquez in Malignant[16], Mariela Vicuna in Brut Force,[17] and Meg in List of a Lifetime where she was nominated for Best Supporting Actress in the 2022 Imagen Awards.