The College was founded in 1952 by the Patrician Brothers to serve mainly rural families of Blacktown and its surrounding districts.

This led to an extensive building program with the addition of 11 classrooms, a technology block, library, a school office, and the Golden Jubilee Hall, as well as an amphitheatre finished in 2013.

During the Arrive Alive Cup in 2007 the Patrician Brothers Blacktown progressed to the grand final.

Former teacher Brother Martin Harmata pleaded guilty to sexually assaulting several boys including students at the school in the 1980s and was jailed for at least 3.5 years on 26 September 2013.

[4] Former Patrician Brother novice and relief teacher Alan James Pollock was also arrested on allegations of sexual abuse of students.

[11] Alan James Pollock pleaded guilty to committing sexual offences against children in September 2014, and was sentenced to eight years gaol in December 2014.

[12][13] The Catholic Education Office has published statements concerning Alan Pollock,[12] Brother Martin Harmata,[14] and Michael Stanton[11] following their convictions.