It is attended by students residing in Del Cerro, San Carlos, Allied Gardens, Mission Valley and the College Area.

Within five years, Patrick Henry became more of a traditional school benefiting from its experimental foundation by the early adoption of advanced placement courses including Art History.

[10] In 2017 the school's robotics club, the Patribots, won the For Inspiration and Recognition of Science and Technology (FIRST) San Diego Regional and competed at the international championships in Houston.

[17] Common projects were carried out with Saint-Michel for the World Forum Lille[18] where cohorts of Patrick Henry High School students presented their work in France on water pollution and the environmental impact of pesticides.

[19] On January 3, 2007 the San Diego Police Department executed a narcotics raid resulting in the arrest of 15 students from Patrick Henry and University City High Schools who allegedly sold narcotics to undercover San Diego Police Department officers posing as students.

[25] On March 17, 2012, a campus police officer was arrested on charges of auto theft and driving under the influence, after taking the wheel of a shuttle-bus while intoxicated.

[26] On March 22, 2012, three Patrick Henry students organized a protest to defend their teachers who had recently been terminated by the San Diego Unified School District.

[27] On our City’s eastern border, Midst the hills and the sky, Home of our most Valiant Patriots, Patrick Henry High.