On the expedition's main southern journey, he led a pony to the foot of the Beardmore glacier, and then became part of the 12-man manhauling party which began the push towards the pole.

He was a member of the first supporting group, along with Edward L. Atkinson, Charles S. Wright and Apsley Cherry-Garrard,[3] to be sent back[4] at 85° 15’ South on 22 December 1911.

On 27 March 1912, Keohane, along with Atkinson, attempted to find Scott and his polar party and bring them back to Cape Evans from the One Ton supply depot.

On 12 November, they found the frozen bodies of Scott, Edward Adrian Wilson, and Henry Robertson Bowers eleven miles south of the One Ton supply depot.

Keohane was portrayed by Larry Burns in the 1948 film Scott of the Antarctic, and by Tom Gerrard in the 1985 television serial The Last Place on Earth.