Patrick Tse began his acting career in the 1950s and remained active for the next 40 years.

In 2022, Tse won his first ever Best Actor award[3] from the Hong Kong Film Critics Society for the movie Time.

[16] Tse's second wife was Deborah Lee (Chinese: 狄波拉), a Hong Kong actress.

Tse and his family lived in Vancouver after his retirement from acting, but they have since returned to Hong Kong.

In 2005, Tse began a relationship with Coco, a Shanghai native who is 49 years his junior.