He debuted in the short film Fragile in Love: Poetry in Motion in 2007 and gained wider recognition for his role in the 2009 television series Autumn's Concerto.

Wu was born on November 24, 1982, in a military dependents' village in Kaohsiung, Taiwan, with his family roots in Anhui.

[11] In 2009, Talking With You Boyfriend's Ex-Girlfriend's director Chen Hui Jing cast him once again in his first idol drama Autumn's Concerto starring Vanness Wu and Ady An, where he played the role of Hua Tuoye.

[11][14][15] During the press conference of TTV's Local Hero in 2011, Wu stated that he accidentally injured his left hand while shooting.

[16] He still participated in their scheduled charity event game that requires peeling fruits despite his hand injury, nevertheless, because he stated that he wanted the kids to enjoy.

[18] In preparation for the role, who is a skinny farmer to be diagnosed of Amyotrophic lateral sclerosis (ALS), Wu started running 5-kilometer races in the hot sun, and ate only boiled eggs and guava.

[19] He also started acting as a father to child actor Chen Yu-cheng a week before filming began to study the father-and-son's lifestyle.

These experiences (doing manual labor jobs at a young age) made me aware of how money is earned that I try my best to be a hardworking actor.

He played the character role of Ouyang Tai, the GM of Shen Da Realty who was engaged to Du Liang Yan, but was later killed by accident.

In 2024, Wu signed with Easy Entertainment, marking his first agency partnership in a decade and expanding his career into mainland China.