On television, he has played David Puddy on Seinfeld,[3] the title character on The Tick, Jeb Denton on Less than Perfect, Jeff Bingham on Rules of Engagement and Lemony Snicket on A Series of Unfortunate Events.

He studied marine biology at Orange Coast College in Costa Mesa, California, but dropped out to pursue modeling and acting.

[10] In the 1990s, Warburton was known for his recurring role in Seinfeld as David Puddy, an unflappable auto mechanic who was the on-again, off-again boyfriend of Elaine Benes (Julia Louis-Dreyfus).

Spade and Warburton reunited for the CBS sitcom Rules of Engagement, which aired from 2007 to 2013, and Joe Dirt 2: Beautiful Loser in 2015.

[12] He appeared on the American version of Top Gear on February 21, 2012, where he set the "Big Star, Small Car" lap record, beating previous record-holder Arlene Tur.

He lent his voice to the droid G2-4T in the queue of Star Tours: The Adventures Continue at Disney's Hollywood Studios in Orlando, Florida and Disneyland in Anaheim, California.

[16][17] His real-life relationship with the Devils began when the team invited him to drop the ceremonial first puck of the 1995 season, and he showed up with his face painted.

In August 2009, he played a high-end PC in a "Get a Mac" ad for Apple Inc.[18] He became the spokesman for Japanese automaker Honda's "Good Reasons" advertising campaign in September 2011.

He is the voice of the current "Discover Fresh" radio ad campaign by Souplantation, a California-based buffet-style restaurant chain (known as Sweet Tomatoes in other markets).

[25] Warburton is a Christian, and has said that he is willing to turn off Family Guy "when it takes its religious humor too far", perceiving such moments "as diminished returns".

[26] His mother, Barbara Warburton, is a member of the Parents Television Council, which is severely critical of Family Guy, on which he voices Joe Swanson.