Pattonsburg is a city in northwest Daviess County, Missouri, United States.

Big Creek flows past east of the town and joins the Grand River approximately two miles to the southeast.

[6] According to the United States Census Bureau, the city has a total area of 0.61 square miles (1.58 km2), all land.

34.3% of all households were made up of individuals, and 18.2% had someone living alone who was 65 years of age or older.

35.0% of all households were made up of individuals, and 15.8% had someone living alone who was 65 years of age or older.

About 20.3% of families and 26.3% of the population were below the poverty line, including 42.5% of those under the age of eighteen and 19.6% of those 65 or over.