His mother was an office administration professor at Niagara College for 30 years in Southern Ontario, while his father was a steel worker.

Bissonnette was named co-captain on the Spirit and also became a member of Canada's under-18 team that won gold medals at the 2003 Nations Cup.

On January 13, 2009, Bissonnette recorded his first career NHL point, assisting on a goal by Tyler Kennedy against the Philadelphia Flyers.

[9] On October 1, 2009, Bissonnette was claimed off waivers by the Phoenix Coyotes after failing to make the Penguins' NHL roster out of training camp.

[12] During the 2011–12 season, on November 19, Bissonnette scored the game-winning goal, playing in front of his mother and grandparents for the first time as an NHL player.

[13] With the 2012–13 NHL lock-out in effect, on November 1, 2012, Bissonnette signed with the Cardiff Devils of the British Elite Ice Hockey League (EIHL).

[17] Bissonnette returned to the Coyotes' organization just three days later on October 27, when he signed a professional tryout agreement with the club's AHL affiliate, the Portland Pirates.

[19] On the same day, Bissonnette signed a tryout agreement with the Manchester Monarchs, the AHL affiliate of the Los Angeles Kings.

[25] On June 24, 2017, it was announced that Bissonnette would join the Coyotes' radio booth as a color commentator, replacing Nick Boynton.

[27] On April 11, 2018, Bissonnette was announced as a new member of the Barstool Sports' podcast, Spittin' Chiclets, joining former Penguins' teammate Ryan Whitney.

[31] In 2021, Turner Sports announced that Bissonnette would be joining the company as a pregame and intermission analyst for the NHL on TNT, alongside Wayne Gretzky, Anson Carter, and Rick Tocchet.

[32] Days later, Bissonnette recounted what occurred on the Spittin' Chiclets podcast, saying it began inside the restaurant, escalated to the parking lot and ended with him taking refuge in a CVS.