Animation in early 2004, Dini went on to write and story edit the first season of the ABC adventure series Lost.

Dini and Timm collaborated on The Batman Adventures: Mad Love, which won the Eisner Award for Best Single Story in 1994.

Dini and illustrator Alex Ross created the graphic novels Superman: Peace on Earth, Batman: War on Crime, Shazam!

Joe cartoon called "Jungle Trap", and contributed to various episodes of the Star Wars: Ewoks animated series,[6] several of which included rare appearances from the Empire.

Freeze as a tragic character and won a Daytime Emmy Award for Outstanding Writing in an Animated Program.

[11] In 1989 and 1990, he contributed scripts to the live-action television horror anthology series Monsters: "One Wolf's Family" and "Talk Nice to Me".

[15][16] Dini won the same Eisner prize the next year as well, for Batman Adventures Holiday Special, (a one-shot with several Christmas-themed stories) with Timm, Ronnie del Carmen, and others.

[19] Dini has written several comics stories for DC Comics, including an oversized graphic novel series illustrated by painter Alex Ross[20] featuring Superman (Superman: Peace on Earth),[21] Batman (Batman: War on Crime),[22] Shazam (Shazam!

[38] Dini co-wrote a draft script for the ill-fated Science Ninja Team Gatchaman movie, which never saw the light of day and resulted in him leaving the project.

[39] Dini wrote a series for Top Cow Productions, based in a character he created, Madame Mirage.

[40] In July 2008, Dini started a partnership with GoAnimate to launch his Super Rica & Rashy series on the platform.

Dini penned the storyline for the Rocksteady Studios video game Batman: Arkham Asylum, released on August 25, 2009.

[48] On August 4, 2010, it was confirmed that Dini will be involved in Marvel Comics' upcoming animated series Ultimate Spider-Man, which aired on Disney XD in 2012.

[57][58] His graphic novel Dark Night: A True Batman Story, based on a mugging he experienced in 1993, was published in June 2016.

[60] Paul Dini and his wife, magician Misty Lee, created an online interview feature called "Monkey Talk" on Kevin Smith's website, Quick Stop Entertainment.com.

[61] Dini and Misty Lee appeared on Ken Reid's TV Guidance Counselor podcast on April 6, 2016.

[62] In September 2020, DC Comics announced that Dini would be among the creators of a revived Batman: Black and White anthology series to debut on December 8, 2020.

Around this time, Dini began an extensive weight loss and exercise regimen which combined dog obedience training.